Resource Type

Journal Article 817

Year

2023 84

2022 105

2021 90

2020 70

2019 47

2018 40

2017 39

2016 40

2015 44

2014 31

2013 38

2012 27

2011 20

2010 19

2009 27

2008 19

2007 30

2006 7

2005 6

2004 7

open ︾

Keywords

3D printing 21

1 8

Deep learning 7

Al2O3 6

Additive manufacturing 5

Machine learning 5

3 4

additive manufacturing 4

drug resistance 4

2 3

FY-3 satellite 3

Optimization 3

hepatocellular carcinoma 3

tissue engineering 3

3-propanediol 2

3D bioprinting 2

3D finite element 2

J-integral 2

Angiogenesis 2

open ︾

Search scope:

排序： Display mode:

Effects of phosphatidylinositol 3-kinase inhibitor on human cervical carcinoma cells

Yuan ZHANG MD , Xiaoyan ZHANG MM , Yanhui LI MM , Xuan DU MM , Zehua WANG MD, PhD , Hongbo WANG MD ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 341-346 doi: 10.1007/s11684-009-0067-9

Abstract: Phosphatidylinositol 3-kinase (PI3K) is a crucial cell survival pathway implicated in tumorigenesis becausestudy was to investigate the regulation of proliferation and apoptosis by LY294002, an inhibitor of PI3KCell viability was measured by 3-(4,5)-dimethylthiazol(-2-y1)-3,5-di-phenyltetrazoliumbromide (MTT) assayThese results suggested that the PI3K/Akt signal pathway might be involved in the regulation of cellMoreover, the regulation of c-FLIP expression through PI3K/Akt signal pathway in cervical cancer cells

Keywords： human cervical cancer cells     apoptosis     phosphatidylinositol 3-kinase (PI3K)/Akt     FLICE-like inhibitory    

HTML PDF Collect

Xiao Ke Qing improves glycometabolism and ameliorates insulin resistance by regulating the PI3K/Akt pathway

Xiaoqing Li, Xinxin Li, Genbei Wang, Yan Xu, Yuanyuan Wang, Ruijia Hao, Xiaohui Ma

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 688-696 doi: 10.1007/s11684-018-0662-8

Abstract: Moreover, XKQ can ameliorate insulin resistance and upregulate the expression of IRS-1, PI3K (p85), p-AktXKQ is an effective drug for T2DM by ameliorating insulin resistance and regulating the PI3K/Akt signaling

Keywords： XKQ     type 2 diabetes mellitus     KKAy mice     PI3K/Akt pathway     diabetic liver disease    

HTML PDF Collect

Ultraviolet-B induced expression of hypoxia-inducible factor 1α, transferrin receptor through EGFR/PI3K/AKT/DEC1 pathway

LI Yanhua, BI Zhigang

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 79-86 doi: 10.1007/s11684-007-0016-4

Abstract: The EGFR/PI3K/AKT signaling pathway was required for the induction of HIF-1α and TfR expression inducedPD153035, a selective inhibitor of EGFR tyrosine kinase, inhibited the TfR protein expression in UVB-treatedPI3K inhibitors, LY294002 and wortmannin, inhibited HIF-1?We conclude that UVB induces TfR and HIF-1αexpressions via EGFR/PI3K/AKT/DEC1 signaling pathway.
HTML PDF Collect

RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 143-155 doi: 10.1007/s11684-022-0929-y

Abstract: Gliomas are the most common central nervous system tumours; they are highly aggressive and have a poor prognosis. RGS16 belongs to the regulator of G-protein signalling (RGS) protein family, which plays an important role in promoting various cancers, such as breast cancer, pancreatic cancer, and colorectal cancer. Moreover, previous studies confirmed that let-7c-5p, a well-known microRNA, can act as a tumour suppressor to regulate the progression of various tumours by inhibiting the expression of its target genes. However, whether RGS16 can promote the progression of glioma and whether it is regulated by miR let-7c-5p are still unknown. Here, we confirmed that RGS16 is upregulated in glioma tissues and that high expression of RGS16 is associated with poor survival. Ectopic deletion of RGS16 significantly suppressed glioma cell proliferation and migration both in vitro and in vivo. Moreover, RGS16 was validated as a direct target gene of miR let-7c-5p. The overexpression of miR let-7c-5p obviously downregulated the expression of RGS16, and knocking down miR let-7c-5p had the opposite effect. Thus, we suggest that the suppression of RGS16 by miR let-7c-5p can promote glioma progression and may serve as a potential prognostic biomarker and therapeutic target in glioma.

Keywords： RGS16     let-7c-5p     glioma     proliferation     migration    

HTML PDF Collect

A 3D porous WP2 nanosheets@carbon cloth flexible electrode for efficient electrocatalytic hydrogen evolution

Mingyu Pi, Xiaodeng Wang, Dingke Zhang, Shuxia Wang, Shijian Chen

Frontiers of Chemical Science and Engineering 2018, Volume 12, Issue 3,   Pages 425-432 doi: 10.1007/s11705-018-1726-7

Abstract: /sub> nanosheet arrays on carbon fiber cloth (WP2 NSs/CC) were synthesized and used as a 3DBecause of its 3D porous nanoarray structure, the WP2 NSs/CC exhibits a remarkable catalyticevolution and provides a way to design and fabricate efficient hydrogen evolution electrodes through 3D

Keywords： WP2     nanosheet arrays     hydrogen evolution electrocatalyst     flexible electrode    

HTML PDF Collect

Fatigue crack growth simulations of 3-D linear elastic cracks under thermal load by XFEM

K. YADAV

Frontiers of Structural and Civil Engineering 2015, Volume 9, Issue 4,   Pages 359-382 doi: 10.1007/s11709-015-0304-z

Abstract: This paper deals with the fatigue crack growth simulations of three-dimensional linear elastic cracks by XFEM under cyclic thermal load. Both temperature and displacement approximations are extrinsically enriched by Heaviside and crack front enrichment functions. Crack growth is modelled by successive linear extensions, and the end points of these linear extensions are joined by cubic spline segments to obtain a modified crack front. Different crack geometries such as planer, non-planer and arbitrary spline shape cracks are simulated under thermal shock, adiabatic and isothermal loads to reveal the sturdiness and versatility of the XFEM approach.

Keywords： 3-D cracks     fatigue life     Paris law     thermal load     XFEM    

HTML PDF Collect

Comparison study on strategies to prepare nanocrystalline Li

Qiang XIAO, Xiaodan TANG, Yefeng LIU, Yijun ZHONG, Weidong ZHU

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 3,   Pages 297-302 doi: 10.1007/s11705-013-1346-1

Abstract: comparison study has been conducted on the strategies for synthesizing nanocrystalline Li ZrO and K-dopedThe doping of K into Li ZrO can significantly improve the uptake rate of CO , especially at low COFor the synthesis of K-doped Li ZrO , the citrate route has poor reproducibility and scalability, whereas

Keywords： CO2 capture     Li2ZrO3     K-doped Li2ZrO3     citrate     starch    

HTML PDF Collect

Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling

Samuel Chege Gitau,Xuelian Li,Dandan Zhao,Zhenfeng Guo,Haihai Liang,Ming Qian,Lifang Lv,Tianshi Li,Bozhi Xu,Zhiguo Wang,Yong Zhang,Chaoqian Xu,Yanjie Lu,Zhiming Du,Hongli Shan,Baofeng Yang

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 444-456 doi: 10.1007/s11684-015-0421-z

Abstract: Aspirin efficiently reversed the upregulation of β-catenin and P-Akt expression and the TAC- orANG II-induced downregulation of GSK-3β.The downregulation of β-catenin and Akt may be the underlying signaling mechanism of the effects

Keywords： aspirin     Akt     cardiac hypertrophy     GSK-3β     Wnt/β-catenin    

HTML PDF Collect

Synthesis of copolymers of 3-acryloyloxymethyl-3′-methyloxetane and 3-(2-(2-(2-Methoxyethylenoxy)ethylenoxy)ethylenoxy)-3′-methyloxetane and their ionic conductivity properties

YE Lin, ZHAO Yumei, FENG Zengguo, BAI Ying, WU Feng

Frontiers of Chemical Science and Engineering 2007, Volume 1, Issue 4,   Pages 343-348 doi: 10.1007/s11705-007-0062-0

Abstract: An oxetane-derived monomer, 3-acryloyloxymethyl-3′-methyloxetane (AMO) was prepared from the reactionof 3-hydromethyl-3-methyloxetane with acryloyl chloride.The cationic ring-opening copolymerization of AMO with another oxetane-derived monomer, 3-(2-(2-(2-methoxyethylenoxy)ethylenoxy)ethylenoxy)-3′-methyloxetane (MEMO) was conducted in CHCl solution using BF3 ·OEt/1, 4-butanediol

Keywords： 4-butanediol     2-methoxyethylenoxy     consistent     oxetane-derived     copolymer    

HTML PDF Collect

Control of peak pressures of an HCCI engine under varying swirl and operating parameters

AMBA PRASAD RAO,K. MADHU MURTHY

Frontiers in Energy 2016, Volume 10, Issue 3,   Pages 337-346 doi: 10.1007/s11708-016-0401-2

Abstract: For computational analysis, the ECFM-3Z model of STAR –CD is considered because it is suitable for analyzingAs an HCCI engine is a hybrid version of SI and CI engines, the ECFM-3Z model with necessary modificationsThe ECFM-3Z model for HCCI mode of combustion is validated with the existing literature to make sure

Keywords： HCCI engine     ECFM-3Z     Swirl ratio     peak pressures     engine speed     piston bowl geometry    

HTML PDF Collect

Heterologous expression of signal protein 14-3-3 in and the subsequent immune response in mice

ZHENG Meijuan, SHEN Jilong, LUO Qingli, XU Yuanhong

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 95-99 doi: 10.1007/s11684-008-0017-y

Abstract: The Sj14-3-3 gene was amplified and subcloned into the expression vector pPICZ?The protein of rSj14-3-3 was prepared and purified and BALB/c mice were immunized which was followedThe Sj14-3-3 gene was expressed and secreted into the medium and its molecular weight was about 35000antibody and rSj14-3-3 had a promising immune reactivity.The recombinant Sj14-3-3 of eukaryotic expression in was successfully harvested.

Keywords： development     challenging     rSj14-3-3     resistance     cultural supernatant    

HTML PDF Collect

GDF15 negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 119-131 doi: 10.1007/s11684-022-0949-7

Abstract: GDF15 improved the tolerance of ESCC cell lines to low-dose cisplatin by regulating AKT phosphorylationAKT and TGFBR2 inhibition resulted in the reversal of the GDF15-induced expression of UGT1A, indicatingthat TGFBR2-AKT pathway-dependent metabolic pathways were involved in the resistance of ESCC cells to

Keywords： GDF15     esophageal squamous cell carcinoma     chemoresistance     cellular metabolism     TGFBR2     AKT    

HTML PDF Collect

FOXP3 and Its Cofactors as Targets of Immunotherapies Review

Yasuhiro Nagai,Lian Lam,Mark I. Greene,Hongtao Zhang

Engineering 2019, Volume 5, Issue 1,   Pages 115-121 doi: 10.1016/j.eng.2019.01.001

Abstract:

Forkhead box P3 (FOXP3) is a "master regulator" of regulatory T cells (Tregs), which areAs a consequence, the PTMs change the stability of FOXP3 and its capability to regulate gene expressionAlthough FOXP3 per se is not an ideal drug target, deacetylases, acetyltransferases, kinases, and other enzymes that regulate the PTMs of FOXP3 are potential targets to modulate FOXP3 and TregFOXP3" side effects must be considered when inhibitors to these enzymes are used.

Keywords： Treg     Forkhead box P3 (FOXP3)     Post-translational modification     Autoimmune     Cancer    

HTML PDF Collect

Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and

Frontiers of Medicine doi: 10.1007/s11684-023-1003-0

Abstract: However, little is known about the function of Lipin3 in triglyceride (TG) metabolism.Hence, we generated Lipin3 heterozygous knockout (Lipin3-heKO) mice and cultured primary hepatocytesto explore the pathophysiological roles of Lipin3 in TG metabolism.Our study suggested that Lipin3 was a novel disease-causing gene inducing obesity and HTG.We also established a relationship between Lipin3 and mitochondrial dysfunction.

Keywords： Lipin3     Lipin1     hypertriglyceridemia     obesity     mitochondrial dysfunction    

HTML PDF Collect

A Review on the 3D Printing of Functional Structures for Medical Phantoms and Regenerated Tissue and

Kan Wang, Chia-Che Ho, Chuck Zhang, Ben Wang

Engineering 2017, Volume 3, Issue 5,   Pages 653-662 doi: 10.1016/J.ENG.2017.05.013

Abstract: With the rapid advancement of three-dimensional (3D) printing and 3D bioprinting technologies, many researchersThis paper reviews the applications of these 3D printing and 3D bioprinting technologies for the fabricationThis review specifically discusses the state of the art along with new developments and trends in 3Dmedical phantoms, radiologically relevant medical phantoms, and physiological medical phantoms) and 3D

Keywords： 3D printing     3D bioprinting     Medical phantom     Regenerated tissue/organ     Scaffold    

HTML PDF Collect

Title Author Date Type Operation

Effects of phosphatidylinositol 3-kinase inhibitor on human cervical carcinoma cells

Yuan ZHANG MD , Xiaoyan ZHANG MM , Yanhui LI MM , Xuan DU MM , Zehua WANG MD, PhD , Hongbo WANG MD ,

Journal Article

Xiao Ke Qing improves glycometabolism and ameliorates insulin resistance by regulating the PI3K/Akt pathway

Xiaoqing Li, Xinxin Li, Genbei Wang, Yan Xu, Yuanyuan Wang, Ruijia Hao, Xiaohui Ma

Journal Article

Ultraviolet-B induced expression of hypoxia-inducible factor 1α, transferrin receptor through EGFR/PI3K/AKT/DEC1 pathway

LI Yanhua, BI Zhigang

Journal Article

RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway

Journal Article

A 3D porous WP2 nanosheets@carbon cloth flexible electrode for efficient electrocatalytic hydrogen evolution

Mingyu Pi, Xiaodeng Wang, Dingke Zhang, Shuxia Wang, Shijian Chen

Journal Article

Fatigue crack growth simulations of 3-D linear elastic cracks under thermal load by XFEM

K. YADAV

Journal Article

Comparison study on strategies to prepare nanocrystalline Li

Qiang XIAO, Xiaodan TANG, Yefeng LIU, Yijun ZHONG, Weidong ZHU

Journal Article

Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling

Samuel Chege Gitau,Xuelian Li,Dandan Zhao,Zhenfeng Guo,Haihai Liang,Ming Qian,Lifang Lv,Tianshi Li,Bozhi Xu,Zhiguo Wang,Yong Zhang,Chaoqian Xu,Yanjie Lu,Zhiming Du,Hongli Shan,Baofeng Yang

Journal Article

Synthesis of copolymers of 3-acryloyloxymethyl-3′-methyloxetane and 3-(2-(2-(2-Methoxyethylenoxy)ethylenoxy)ethylenoxy)-3′-methyloxetane and their ionic conductivity properties

YE Lin, ZHAO Yumei, FENG Zengguo, BAI Ying, WU Feng

Journal Article

Control of peak pressures of an HCCI engine under varying swirl and operating parameters

AMBA PRASAD RAO,K. MADHU MURTHY

Journal Article

Heterologous expression of signal protein 14-3-3 in and the subsequent immune response in mice

ZHENG Meijuan, SHEN Jilong, LUO Qingli, XU Yuanhong

Journal Article

GDF15 negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal

Journal Article

FOXP3 and Its Cofactors as Targets of Immunotherapies

Yasuhiro Nagai,Lian Lam,Mark I. Greene,Hongtao Zhang

Journal Article

Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and

Journal Article

A Review on the 3D Printing of Functional Structures for Medical Phantoms and Regenerated Tissue and

Kan Wang, Chia-Che Ho, Chuck Zhang, Ben Wang

Journal Article